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1

Pharmacokinetic, biologic and epidemiologic differences in MPA- and NET-based progestin-only injectable contraceptives relative to the potential impact on HIV acquisition in women

Heffron, Renee, Achilles, Sharon L., Dorflinger, Laneta J., Hapgood, Janet P., Kiarie, James, Polis, Chelsea B., Steyn, Petrus S.

Journal:

Year:

2018

Language:

english

File:

PDF, 374 KB

english, 2018

2

Amplification, Sequence and Expression of the Harpin Encoding Gene of the Bacterial Canker Pathogen, Pseudomonas syringae pv. syringae Strain NV

Maryke Appel, Mathias Hampf, Lucienne Mansvelt, Janet Hapgood, Dirk Bellstedt

Journal:

Journal of Plant Physiology

Year:

1999

Language:

english

File:

PDF, 1.31 MB

english, 1999

3

Covalent labelling of histones with aurothiomalate : Gold-labelled H2A-H2B dimers assemble to octamers, which form crystalline helical tubes

H. Johann GREYLING, Janet P. HAPGOOD, B. Trevor SEWELL, Claus VON HOLT

Journal:

Year:

1986

Language:

english

File:

PDF, 1.30 MB

english, 1986

4

The Contraceptive MPA, Unlike NET, Modulates Expression of Immune Function Genes and Increases HIV-1 Infection in Cervical Tissue Explants and PBMCs

Ray, Roslyn M., Avenant, Chanel, Moliki, Johnson M., Hapgood, Janet P.

Journal:

AIDS Research and Human Retroviruses

Year:

2014

Language:

english

File:

PDF, 59 KB

english, 2014

5

Modulation of HIV-1 virulence via the host glucocorticoid receptor: towards further understanding the molecular mechanisms of HIV-1 pathogenesis

Janet Patricia Hapgood, Michele Tomasicchio

Journal:

Archives of Virology

Year:

2010

Language:

english

File:

PDF, 329 KB

english, 2010

6

Differential nuclear localisation and promoter occupancy play a role in glucocorticoid receptor ligand-specific transcriptional responses

Katie E. Hadley, Ann Louw, Janet P. Hapgood

Journal:

Year:

2011

Language:

english

File:

PDF, 914 KB

english, 2011

7

Glucocorticoid Receptor Phosphorylation Modulates Transcription Efficacy through GRIP-1 Recruitment

Avenant, Chanel, Kotitschke, Andrea, Hapgood, Janet P.

Journal:

Year:

2010

Language:

english

File:

PDF, 3.03 MB

english, 2010

8

Two Gonadotropin-Releasing Hormone Receptor Subtypes with Distinct Ligand Selectivity and Differential Distribution in Brain and Pituitary in the Goldfish (Carassius auratus)

Nicola Illing, Brigitte E. Troskie, Carol S. Nahorniak, Janet P. Hapgood, Richard E. Peter and Robert P. Millar

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.49 MB

english, 1999

9

Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy

Hapgood, Janet P., Avenant, Chanel, Moliki, Johnson M.

Journal:

Pharmacology & Therapeutics

Year:

2016

Language:

english

File:

PDF, 2.13 MB

english, 2016

10

Corrigendum to “Pharmacokinetic, biologic and epidemiologic differences in MPA- and NET-based progestin-only injectable contraceptives relative to the potential impact on HIV acquisition in women” [Contraception 99 (2019) 199–204]

Heffron, Renee, Achilles, Sharon L., Dorflinger, Laneta J., Hapgood, Janet P., Kiarie, James, Polis, Chelsea B., Steyn, Petrus S.

Journal:

Year:

2019

Language:

english

File:

PDF, 207 KB

english, 2019

11

A direct comparison of the transcriptional activities of progestins used in contraception and menopausal hormone therapy via the mineralocorticoid receptor

Louw-du Toit, Renate, Hapgood, Janet P., Africander, Donita

Journal:

Biochemical and Biophysical Research Communications

Year:

2020

File:

PDF, 1.18 MB

2020

12

Incorporation of an additional glycosylation site enhances expression of functional human gonadotropin-releasing hormone receptor

James S. Davidson, Colleen A. Flanagan, Peter D. Davies, Janet Hapgood, David Myburgh, Ricardo Elario, Robert P. Millar, Wynn Forrest-Owen, Craig A. McArdle

Journal:

Endocrine (Springer)

Year:

1996

Language:

english

File:

PDF, 724 KB

english, 1996

13

Corrigendum to “Pharmacokinetic, biologic and epidemiologic differences in MPA- and NET-based progestin-only injectable contraceptives relative to the potential impact on HIV acquisition in women” [Contraception 99 (2019) 199–204]

Heffron, Renee, Achilles, Sharon L., Dorflinger, Laneta J., Hapgood, Janet P., Kiarie, James, Polis, Chelsea B., Steyn, Petrus S.

Journal:

Year:

2019

File:

PDF, 207 KB

2019

14

Differential regulation of endogenous pro-inflammatory cytokine genes by medroxyprogesterone acetate and norethisterone acetate in cell lines of the female genital tract

Donita Africander, Renate Louw, Nicolette Verhoog, Dewald Noeth, Janet P. Hapgood

Journal:

Year:

2011

Language:

english

File:

PDF, 338 KB

english, 2011

15

ECHO: context and limitations

Hapgood, Janet P

Journal:

Lancet (London, England)

Year:

2020

File:

PDF, 32 KB

2020

16

Irreversible Activation of the Gonadotropin-Releasing Hormone Receptor by Photoaffinity Cross-Linking: Localization of Attachment Site to Cys Residue in N-Terminal Segment

Davidson, James S., Assefa, Daniel, Pawson,, Davies,, Hapgood, Janet, Becker,, Flanagan,, Roeske, Roger, Millar,

Journal:

Year:

1997

Language:

english

File:

PDF, 298 KB

english, 1997

17

The Injectable-Only Contraceptive Medroxyprogesterone Acetate, Unlike Norethisterone Acetate and Progesterone, Regulates Inflammatory Genes in Endocervical Cells via the Glucocorticoid Receptor

Govender, Yashini, Avenant, Chanel, Verhoog, Nicolette J. D., Ray, Roslyn M., Grantham, Nicholas J., Africander, Donita, Hapgood, Janet P., Thomas, Paul G.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.70 MB

english, 2014

18

Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception

Donita Africander, Nicolette Verhoog, Janet P. Hapgood

Journal:

Year:

2011

Language:

english

File:

PDF, 1.07 MB

english, 2011

19

Ligand-dependent interaction of the dioxin receptor with target DNA

Scott Cuthill, Janet Hapgood, Marc Denis, Anna Wilhelmsson, Grant Mason, Nemoto Takayuki, Eva Widmark, Lorenz Poellinger, Jan-Åke Gustafsson

Journal:

Journal of Steroid Biochemistry

Year:

1989

Language:

english

File:

PDF, 420 KB

english, 1989

20

Not all progestins are the same: implications for usage

Janet P. Hapgood, Dominique Koubovec, Ann Louw, Donita Africander

Journal:

Trends in Pharmacological Sciences

Year:

2004

Language:

english

File:

PDF, 252 KB

english, 2004

21

Differential Glucocorticoid Receptor-Mediated Effects on Immunomodulatory Gene Expression by Progestin Contraceptives: Implications for HIV-1 Pathogenesis

Hapgood, Janet P., Ray, Roslyn M., Govender, Yashini, Avenant, Chanel, Tomasicchio, Michele

Journal:

American Journal of Reproductive Immunology

Year:

2014

Language:

english

File:

PDF, 386 KB

english, 2014

22

The use of sulfosuccinimidyl-2-(p-azidosalicylamido)-1,3′-dithiopropionate as a crosslinking reagent to identify cell surface receptors

Enid G. Shephard, Frederick C. de Beer, Claus von Holt, Janet P. Hapgood

Journal:

Analytical Biochemistry

Year:

1988

Language:

english

File:

PDF, 1.38 MB

english, 1988

23

Expression of the Mouse Gonadotropin-Releasing Hormone Receptor Gene in αT3-1 Gonadotrope Cells Is Stimulated by Cyclic 3′,5′-Adenosine Monophosphate and Protein Kinase A, and Is Modulated by Steroidogenic Factor-1 and Nur77

Sadie, Hanél, Styger, Gustav, Hapgood, Janet

Journal:

Year:

2003

Language:

english

File:

PDF, 524 KB

english, 2003

24

REGULATION OF GENE EXPRESSION BY GC-RICH DNA CIS -ELEMENTS

Janet P. Hapgood, Johann Riedemann, Sonja D. Scherer

Journal:

Cell Biology International

Year:

2001

Language:

english

File:

PDF, 240 KB

english, 2001

25

Investigating the anti-mineralocorticoid properties of synthetic progestins used in hormone therapy

Africander, Donita, Louw, Renate, Hapgood, Janet P.

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 347 KB

english, 2013

26

Is a lower-dose, subcutaneous contraceptive injectable containing depot medroxyprogesterone acetate likely to impact women's risk of HIV?

Polis, Chelsea B., Achilles, Sharon L., Hel, Zdenek, Hapgood, Janet P.

Journal:

Year:

2017

Language:

english

File:

PDF, 273 KB

english, 2017

27

Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cells

Dominique Koubovec, Wim Vanden Berghe, Linda Vermeulen, Guy Haegeman, Janet Patricia Hapgood

Journal:

Molecular and Cellular Endocrinology

Year:

2004

Language:

english

File:

PDF, 306 KB

english, 2004

28

Glucocorticoid receptor concentration and the ability to dimerize influence nuclear translocation and distribution

Robertson, Steven, Hapgood, Janet P., Louw, Ann

Journal:

Year:

2013

Language:

english

File:

PDF, 714 KB

english, 2013

29

Rat liver glucocorticoid receptor isolated by affinity chromatography is not a magnesium- or calcium-dependent protein kinase

Hapgood, Janet P., Sabbatini, Gregory P., Von Holt, Claus

Journal:

Year:

1986

Language:

english

File:

PDF, 3.33 MB

english, 1986

30

Immunosuppressive Biological Mechanisms Support Reassessment of Use of the Injectable Contraceptive Medroxyprogesterone Acetate

Hapgood, Janet P.

Journal:

Year:

2013

Language:

english

File:

PDF, 52 KB

english, 2013

31

Comparing the androgenic and estrogenic properties of progestins used in contraception and hormone therapy

Louw-du Toit, Renate, Perkins, Meghan S., Hapgood, Janet P., Africander, Donita

Journal:

Biochemical and Biophysical Research Communications

Year:

2017

Language:

english

File:

PDF, 930 KB

english, 2017

32

HIV-1 Latency Is Maintained by the Estrogen Receptor

Bick, Alexis J., Hapgood, Janet P.

Journal:

Trends in Microbiology

Year:

2018

Language:

english

File:

PDF, 438 KB

english, 2018

33

Transformation in vitro and covalent modification with biotin of steroid-affinity-purified rat-liver glucocorticoid-hormone-receptor complex

Janet P. HAPGOOD, Claus von HOLT

Journal:

Year:

1987

Language:

english

File:

PDF, 620 KB

english, 1987

34

Steroid-affinity purification of the rat liver glucocorticoid hormone receptor complex

Janet P. Hapgood, Claus Von Holt

Journal:

Journal of Steroid Biochemistry

Year:

1987

Language:

english

File:

PDF, 1.24 MB

english, 1987

35

Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction

Katharina Ronacher, Katie Hadley, Chanel Avenant, Elisabeth Stubsrud, S. Stoney Simons Jr., Ann Louw, Janet P. Hapgood

Journal:

Molecular and Cellular Endocrinology

Year:

2009

Language:

english

File:

PDF, 1.26 MB

english, 2009

36

Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects

Stanczyk, Frank Z., Hapgood, Janet P., Winer, Sharon, Mishell, Daniel R.

Journal:

Endocrine Reviews

Year:

2013

Language:

english

File:

PDF, 964 KB

english, 2013

37

Role of ligand-dependent GR phosphorylation and half-life in determination of ligand-specific transcriptional activity

Chanel Avenant, Katharina Ronacher, Elisabeth Stubsrud, Ann Louw, Janet P. Hapgood

Journal:

Molecular and Cellular Endocrinology

Year:

2010

Language:

english

File:

PDF, 1.38 MB

english, 2010

38

Targeting the Glucocorticoid Receptor with Selective Modulators for Prevention against HIV-1 Infection

Avenant, Chanel, Tomasicchio, Michele, Ray, Roslyn Michelle, Du Toit, Andrea, Govender, Yashini, Hunt, Hazel, Hapgood, Janet Patricia

Journal:

AIDS Research and Human Retroviruses

Year:

2014

Language:

english

File:

PDF, 61 KB

english, 2014

39

Genomic and Nongenomic Cross Talk between the Gonadotropin-Releasing Hormone Receptor and Glucocorticoid Receptor Signaling Pathways

Kotitschke, Andrea, Sadie-Van Gijsen, Hanél, Avenant, Chanel, Fernandes, Sandra, Hapgood, Janet P.

Journal:

Molecular Endocrinology

Year:

2009

Language:

english

File:

PDF, 747 KB

english, 2009

40

Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms

Hapgood, Janet P, Kaushic, Charu, Hel, Zdenek

Journal:

Endocrine Reviews

Year:

2018

Language:

english

File:

PDF, 1.78 MB

english, 2018

41

Inhibition of Corticosteroid-Binding Globulin Gene Expression by Glucocorticoids Involves C/EBPβ

Verhoog, Nicolette, Allie-Reid, Fatima, Vanden Berghe, Wim, Smith, Carine, Haegeman, Guy, Hapgood, Janet, Louw, Ann, Sun, Kang

Journal:

Year:

2014

Language:

english

File:

PDF, 1.40 MB

english, 2014

42

Medroxyprogesterone acetate, unlike norethisterone, increases HIV-1 replication in human peripheral blood mononuclear cells and an indicator cell line, via mechanisms involving the glucocorticoid receptor, increased CD4/CD8 ratios and CCR5 levels

Maritz, Michelle F., Ray, Roslyn M., Bick, Alexis J., Tomasicchio, Michele, Woodland, John G., Govender, Yashini, Avenant, Chanel, Hapgood, Janet P., Mummidi, Srinivas

Journal:

Year:

2018

Language:

english

File:

PDF, 5.98 MB

english, 2018

43

Specific Protein-DNA Interactions at a Xenobiotic-Responsive Element: Copurification of Dioxin Receptor and DNA-Binding Activity

Janet Hapgood, Scott Cuthill, Marc Denis, Lorenz Poellinger and Jan-Åke Gustafsson

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 960 KB

english, 1989

44

Alanine-261 in intracellular loop III of the human gonadotropin-releasing hormone receptor is crucial for G-protein coupling and receptor internalization

MYBURGH, David B., MILLAR, Robert P., HAPGOOD, Janet P.

Journal:

Biochemical Journal

Year:

1998

Language:

english

File:

PDF, 263 KB

english, 1998

45

The injectable contraceptive medroxyprogesterone acetate attenuates Mycobacterium tuberculosis -specific host immunity through the glucocorticoid receptor

Tomasicchio, Michele, Davids, Malika, Pooran, Anil, Theron, Grant, Smith, Liezel, Semple, Lynn, Meldau, Richard, Hapgood, Janet Patricia, Dheda, Keertan

Journal:

The Journal of Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 1.03 MB

english, 2018

46

Characterisation of progestins used in hormonal contraception and progesterone via the progesterone receptor

Enfield, Kim, Cartwright, Meghan, Toit, Renate Louw-du, Avenant, Chanel, Africander, Donita, Hapgood, Janet P.

Journal:

Biochemical and Biophysical Research Communications

Year:

2020

File:

PDF, 1.71 MB

2020

47

Synthetic progestins used in HRT have different glucocorticoid agonist properties

Dominique Koubovec, Katharina Ronacher, Elisabeth Stubsrud, Ann Louw, Janet Patricia Hapgood

Journal:

Molecular and Cellular Endocrinology

Year:

2005

Language:

english

File:

PDF, 314 KB

english, 2005

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